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January 1, 2026Journal of Immunology ResearchOpen Access

Chaiyin Granules Improve Acute Lung Injury by Regulating Gut Microbiota and Unsaturated Fatty Acid Mediated Wnt/β‐Catenin Signaling Pathway

Wenting Ni He Xiao Qun Feng Shirong Li Jingchun Yao Guimin Zhang

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Key Points

The study aims to explore how Chaiyin granules improve acute lung injury by regulating gut microbiota and inflammatory pathways.
Established LPS-induced acute lung injury mouse model to evaluate Chaiyin granules' efficacy.
Analyzed gut microbiota and metabolites using 16S rRNA and metabolomics.
Utilized hematoxylin-eosin staining and ELISA to assess lung tissue damage and inflammatory response.
Chaiyin granules significantly reduced lung injury and inflammatory markers in ALI mice (p<0.05).
Improved intestinal barrier function and levels of unsaturated fatty acids identified in treated mice.
Wnt/β-catenin pathway was confirmed as a key mechanism for Chaiyin granules' therapeutic effects.

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Implication

Investigates Chaiyin granules' effects on acute lung injury via gut microbiota regulation, highlighting clinical implications.

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Cite This Study

Ni et al. (2026) studied this question.

synapsesocial.com/papers/6a23bad471a5da9775e766bf https://doi.org/10.1155/jimr/7225946

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