Long-term Safety of Idebenone in Patients With Leber Hereditary Optic Neuropathy With Alcohol or Tobacco Use/Abuse or Vitamin B12 Deficiency: Results From the PAROS Study (P10-17.006)

Nancy Newman; Berthold Pemp; Thomas Klopstock; Xavier Llòria; Valerio Carelli

doi:10.1212/wnl.0000000000215439

June 9, 2026Neurology

Long-term Safety of Idebenone in Patients With Leber Hereditary Optic Neuropathy With Alcohol or Tobacco Use/Abuse or Vitamin B12 Deficiency: Results From the PAROS Study (P10-17.006)

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Key Points

This research aims to evaluate the long-term safety of idebenone in patients with Leber hereditary optic neuropathy, particularly those with substance use or vitamin deficiencies.
Conducted as part of the PAROS study
Focused on patients with LHON and a background of alcohol or tobacco use or vitamin B12 deficiency
Utilized real-world data to assess safety outcomes
Observations highlight the acceptable safety profile of idebenone in the specified patient population
Findings indicate minimal adverse effects related to idebenone usage among participants with substance use or vitamin deficiencies

Implication

Reveals long-term safety of idebenone in patients with LHON and substance use history, indicating its potential benefit.

Abstract

To describe, from the PAROS study, real-world long-term idebenone safety in patients with Leber hereditary optic neuropathy (LHON) and a history of alcohol or tobacco use/abuse or vitamin B12 deficiency.

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Cite This Study

Newman et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f056267 https://doi.org/10.1212/wnl.0000000000215439

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Long-term Safety of Idebenone in Patients With Leber Hereditary Optic Neuropathy With Alcohol or Tobacco Use/Abuse or Vitamin B12 Deficiency: Results From the PAROS Study (P10-17.006)

Key Points

Implication

Abstract

Discussion

Cite This Study

Long-term Safety of Idebenone in Patients With Leber Hereditary Optic Neuropathy With Alcohol or Tobacco Use/Abuse or Vitamin B12 Deficiency: Results From the PAROS Study (P10-17.006)

Key Points

Implication

Abstract

Discussion

Cite This Study

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