Direct Oral Anticoagulants for Cerebral Venous Thrombosis: Equivalent Efficacy, Superior Safety Compared to Vitamin K Antagonists (P3-4.003)

Mohammad Munim Zahoor; Muhammad Talha Maqsood; Ahsan Abid; Nabeeha Noor; Ezza Bashir; Huda Memon; David Ermak

doi:10.1212/wnl.0000000000215019

June 9, 2026Neurology

Direct Oral Anticoagulants for Cerebral Venous Thrombosis: Equivalent Efficacy, Superior Safety Compared to Vitamin K Antagonists (P3-4.003)

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Key Points

This research aims to systematically review and compare the efficacy and safety of direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) for treating cerebral venous thrombosis (CVT).
Conducted the largest systematic review and meta-analysis to date on the topic.
Compared the efficacy, safety, and treatment durability of DOACs and VKAs in patients with CVT.
DOACs demonstrate equivalent efficacy compared to VKAs in treating CVT.
DOACs show superior safety profiles, leading to fewer complications than VKAs.

Implication

Systematic review shows equivalent efficacy and superior safety of DOACs versus VKAs in cerebral venous thrombosis, indicating a better treatment option.

Abstract

To perform the largest systematic review and meta-analysis comparing DOACs and VKAs in CVT, evaluating efficacy, safety, and treatment durability to date.

Discussion

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Cite This Study

Zahoor et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf403faef96ed7f056616 https://doi.org/10.1212/wnl.0000000000215019

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Direct Oral Anticoagulants for Cerebral Venous Thrombosis: Equivalent Efficacy, Superior Safety Compared to Vitamin K Antagonists (P3-4.003)

Key Points

Implication

Abstract

Discussion

Cite This Study

Direct Oral Anticoagulants for Cerebral Venous Thrombosis: Equivalent Efficacy, Superior Safety Compared to Vitamin K Antagonists (P3-4.003)

Key Points

Implication

Abstract

Discussion

Cite This Study

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