Case report shows that dextromethorphan effectively treats stroke-like encephalopathy from methotrexate, indicating a potential therapeutic option for adults.
•To report that MTX-induced stroke-like encephalopathy can respond to the N-methyl-D-aspartate receptor agonist dextromethorphan at a dose range of 1.4–2.3 mg/kg/day for 4–14 doses in adults.
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Persico et al. (2026) studied this question.
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