Concordance and divergence between self-declared ancestry and genome-derived ancestry composition in 10,250 participants from the HostSeq cohort

May 27, 2026Open Access

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Key Points

The aim is to analyze the agreement and differences between self-reported ancestry and genetically determined ancestry in a large cohort.
Analyzed ancestry data from 10,250 participants in the HostSeq cohort.
Compared self-declared ancestry with genome-derived ancestry compositions.
Statistical analyses were conducted to assess concordance.
Significant discrepancies were observed between self-declared and genome-derived ancestry.
Certain ancestries were more accurately self-reported than others.
Results highlight the potential for enhanced understanding of genetic ancestry.

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Evaluates ancestry concordance in 10,250 participants, suggesting genetic insights align with self-identification.

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René L. Warren (2026) studied this question.

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