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June 13, 2026Open Access

Concordance and divergence between self-declared ancestry and genome-derived ancestry composition in 10,250 participants from the HostSeq cohort

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Authors

RWRené L. Warren

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Overview

Randomized trial evaluates ancestry concordance in 10,250 participants, suggesting genetic insights align with self-identification.

Key Points

  • The aim is to analyze the agreement and differences between self-reported ancestry and genetically determined ancestry in a large cohort.
  • Analyzed ancestry data from 10,250 participants in the HostSeq cohort.
  • Compared self-declared ancestry with genome-derived ancestry compositions.
  • Statistical analyses were conducted to assess concordance.
  • Significant discrepancies were observed between self-declared and genome-derived ancestry.
  • Certain ancestries were more accurately self-reported than others.
  • Results highlight the potential for enhanced understanding of genetic ancestry.

Cite This Study

René L. Warren (2026) studied this question.

synapsesocial.com/papers/6a2cf45afaef96ed7f056978https://doi.org/10.5281/zenodo.20636558
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Concordance and divergence between self-declared ancestry and genome-derived ancestry composition in 10,250 participants from the HostSeq cohort2026
  2. 2A harmonized public resource of deeply sequenced diverse human genomes2024 · 135 citations
  3. 3Table S1 from Development and Application of Genetic Ancestry Reconstruction Methods to Study Diversity of Patient-Derived Models in the NCI PDXNet Consortium2024
  4. 4Table S1 from Development and Application of Genetic Ancestry Reconstruction Methods to Study Diversity of Patient-Derived Models in the NCI PDXNet Consortium2024
  5. 5Table S1 from Development and Application of Genetic Ancestry Reconstruction Methods to Study Diversity of Patient-Derived Models in the NCI PDXNet Consortium2024