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July 26, 2026Genome

Concordance and divergence between self-declared ancestry and genome-derived ancestry composition in 10,250 participants from the HostSeq cohort

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Authors

RWRene WarrenBC Cancer AgencyLCLauren CoombeBC Cancer AgencyİBİnanç BirolUniversity of British Columbia

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Overview

Randomized trial compares self-declared and genome-derived ancestry in 10,250 participants, indicating a need for nuanced ancestral representation.

Key Points

  • This research aims to compare self-declared ancestry with genome-derived ancestry composition among a large cohort.
  • Analyzed whole-genome sequencing data from 10,250 participants in the HostSeq cohort.
  • Used the ntRoot algorithm to infer global and local ancestry at the continental super-population level.
  • Evaluated ancestry through both hard-label concordance and multiclass Brier score analyses.
  • Strong agreement was found among East Asian/Pacific Islander, Black, White, and South Asian participants with low mean Brier scores.
  • Hispanic and Middle Eastern participants exhibited higher Brier scores, indicating more complex ancestry profiles.
  • Findings suggest ancestry should be viewed as a continuous spectrum rather than fixed categories.

Cite This Study

Warren et al. (2026) studied this question.

synapsesocial.com/papers/6a65a6b5d3aea3239cd77dc2https://doi.org/10.1139/gen-2026-0022
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Concordance and divergence between self-declared ancestry and genome-derived ancestry composition in 10,250 participants from the HostSeq cohort2026
  2. 2Integrating genetic ancestry into clinical care: Accuracy, utility, and stakeholder views2026 · 1 citations
  3. 3The Complex Relationship of Genetic Ancestry With Self‐Reported Race/Ethnicity2025 · 3 citations
  4. 4A Method for Inferring an Individual’s Genetic Ancestry and Degree of Admixture Associated with Six Major Continental Populations2013 · 35 citations
  5. 5Human ancestry inference at scale, from genomic data2024 · 2 citations