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October 18, 2025Genetic EpidemiologyOpen Access

The Complex Relationship of Genetic Ancestry With Self‐Reported Race/Ethnicity

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Authors

YBYambazi BandaNRNeil Risch

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Overview

Analysis reveals the connection between genetic ancestry and self-reported ethnicity in 97,671 participants, suggesting implications for biomedical research.

Key Points

  • Self-identification as African American, East Asian, and Latino(a) rises with modest amounts of respective genetic ancestry.
  • Overwhelmingly, genetically admixed individuals self-identify with minority race/ethnicity groups, even with primarily European ancestry.
  • Contrarily, self-reporting as Native American does not correlate with actual Native American genetic ancestry.
  • Findings indicate significant implications for how race and ethnicity should be considered in biomedical research.

Cite This Study

Banda et al. (2025) studied this question.

synapsesocial.com/papers/68f3d0c11cb4135751d12c66https://doi.org/10.1002/gepi.70019
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic Ancestry and Self-Reported “Skin Color/Race” in the Urban Admixed Population of São Paulo City, Brazil2024 · 11 citations
  2. 2Implications of self-identified race, ethnicity, and genetic ancestry on genetic association studies in biobanks within health systems2024 · 2 citations
  3. 3Concordance and divergence between self-declared ancestry and genome-derived ancestry composition in 10,250 participants from the HostSeq cohort2026
  4. 4Association of genetic ancestry with molecular tumor profiles in colorectal cancer2024 · 20 citations
  5. 5Race/Ethnicity/Ancestry (REA) and Disease: A Complex Interplay of Social and Biological Factors2026