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April 3, 2026Journal of Community GeneticsOpen Access

Integrating genetic ancestry into clinical care: Accuracy, utility, and stakeholder views

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Authors

JPJessica PrettymanUniversity of California, San FranciscoTHThomas J. HoffmannUniversity of California, San FranciscoSBSawona BiswasUniversity of California, San Francisco

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Implication

Analysis evaluates genetic ancestry integration's accuracy and utility in clinical settings, highlighting stakeholder perspectives and implications.

Key Points

  • This research aims to assess the accuracy of genetic ancestry integration in clinical care and explore stakeholder perspectives.
  • Analyzed data from 451 adults participating in the UCSF 3D Health Study.
  • Evaluated agreement between two commercial ancestry providers.
  • Measured concordance between ancestry algorithms and self-identified race/ethnicity recorded in the electronic health record.
  • Conducted a survey of participant perspectives regarding ancestry accuracy and EHR integration.
  • Mean agreement between two ancestry providers was 58.4% overall, varying by ancestry category.
  • Concordance with self-identified race/ethnicity at ≥90% was significantly variable, with ancestry algorithms showing rates from 2.6% to 89.3%.
  • Majority of surveyed participants expressed neutrality or support for ancestry reporting's accuracy, but concerns about discrimination were prevalent.

Cite This Study

Prettyman et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e015a333a821460c17ahttps://doi.org/10.1007/s12687-026-00880-0
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Also Consider

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  1. 1The 100 000 Genomes Project: bringing whole genome sequencing to the NHS2018 · 489 citations
  2. 2Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort2015 · 362 citations
  3. 3Hidden in Plain Sight — Reconsidering the Use of Race Correction in Clinical Algorithms2020 · 1,754 citations
  4. 4The Social Determinants of Health: It's Time to Consider the Causes of the Causes2014 · 3,879 citations
  5. 5Do genetic ancestry tests increase racial essentialism? Findings from a randomized controlled trial2020 · 80 citations