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June 13, 2026Endocrine Reviews

Regulators of Appetite in Mammals – Old and New players

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Authors

JFJorge H FernandesJSJorge Diogo SilvaMCMarta D Costa

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Overview

Review analyzes novel and traditional mechanisms of appetite regulation in mammals, suggesting implications for therapy development.

Key Points

  • The review examines complex mechanisms regulating appetite in mammals, focusing on both traditional and newly discovered players.
  • Compiles and analyzes recent findings on appetite control mechanisms in mammals.
  • Explores molecular pathways in appetite regulation with emphasis on the hypothalamus and specific neuropeptides.
  • Investigates implications for drug discovery targeting appetite-related disorders.
  • Identifies overlapping pathways in homeostatic and hedonic feeding, particularly in the hypothalamus and mesolimbic system.
  • Highlights the role of various neuropeptides and receptor systems in appetite regulation.
  • Suggests that understanding these systems can inform therapies for obesity, anorexia nervosa, and binge-eating disorder.

Cite This Study

Fernandes et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf488faef96ed7f056cf0https://doi.org/10.1210/endrev/bnag020
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