Study constructs eight-membered iminosugars using enamine and alkyne, indicating a novel synthesis approach.
In this study, the target eight-membered iminosugars were constructed in one pot via [2 + 2] cycloaddition between the key enamine and alkyne moieties, followed by ring expansion, using amines, sugars bearing easily cleavable protecting groups at the terminal position, and butynoate esters as starting materials. This work provides a convenient skeletal editing strategy for the synthesis of uncommon eight-membered nitrogen-containing heterocycles.
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Yang et al. (2026) studied this question.
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