Systematic review evaluates fMRI predictors of treatment outcomes in individuals with AUD, suggesting implications for precision medicine.
Key Points
This review aims to synthesize evidence on fMRI predictors of treatment outcomes in individuals with Alcohol Use Disorder (AUD) and identify methodological gaps.
Comprehensive literature search of PubMed/MEDLINE, Embase, and PsycINFO was conducted.
Eligible studies included participants with AUD who received pharmacological, behavioral, or neuromodulatory interventions with fMRI measures.
Study quality was assessed using the Grading of Recommendations Assessment, Development, and Evaluation framework.
Fifteen studies met inclusion criteria, with the majority focusing on alcohol cue reactivity tasks.
Neural activity in the ventral striatum, orbitofrontal cortex, and anterior cingulate cortex was commonly predictive of treatment outcomes.
Heterogeneity in study findings and small sample sizes limit the strength of conclusions drawn.