What question did this study set out to answer?

To identify the neural substrates underlying alcohol cue reactivity and evaluate which brain regions reliably differentiate individuals with alcohol use disorders from healthy controls.

May 10, 2012Addiction BiologyOpen Access

Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta‐analysis and systematic review

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Authors

JSJoseph P. SchachtUniversity of Colorado Anschutz Medical Campus RARaymond F. AntonMedical University of South Carolina HMHugh MyrickBoston University

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Implication

Meta-analysis reveals heightened parietal and temporal cue reactivity in alcohol use disorder, suggesting these regions differentiate patients from controls beyond classic limbic pathways.

Key Points

To identify the neural substrates underlying alcohol cue reactivity and evaluate which brain regions reliably differentiate individuals with alcohol use disorders from healthy controls.
Conducted a systematic review and activation likelihood estimation meta-analysis across 28 functional neuroimaging studies comprising 679 cases and 174 controls.
Assessed differential activation patterns between cases and controls, along with correlations between cue-elicited brain activity, behavioral measures, and clinical treatment effects.
Cases showed robust cue-elicited activation within mesolimbic and prefrontal circuits, including the ventral striatum, anterior cingulate cortex, and ventromedial prefrontal cortex.
Compared with controls, cases exhibited significantly greater activation in parietal and temporal areas, specifically the posterior cingulate cortex, precuneus, and superior temporal gyrus.
Ventral striatum activation correlated most consistently with behavioral craving measures and treatment-related reductions, although these analyses predominantly targeted pre-selected limbic regions of interest.

Cite This Study

Schacht et al. (2012) studied this question.

synapsesocial.com/papers/6a76fa2c98f24dbf64bd62d6 https://doi.org/10.1111/j.1369-1600.2012.00464.x

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Implication

Meta-analysis reveals heightened parietal and temporal cue reactivity in alcohol use disorder, suggesting these regions differentiate patients from controls beyond classic limbic pathways.

Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta‐analysis and systematic review

Discussion

Member takes

Implication

Key Points

Cite This Study

Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta‐analysis and systematic review

Discussion

Member takes

Implication

Key Points

Cite This Study

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