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June 13, 2026AntioxidantsOpen Access

Sex-Specific and Reproductive Status-Dependent Effects of Liraglutide on Metabolic Disorders Associated with Prediabetes

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Authors

LLLucie LebertováIMIrena MarkováMHMartina Hüttl

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Overview

Randomized trial investigates liraglutide's impact on metabolic disorders based on sex and reproductive status, showing significant improvements in female rats.

Key Points

  • This research aims to understand how liraglutide affects metabolic disorders related to prediabetes, considering sex and reproductive status.
  • Used male, female, and ovariectomized female hereditary hypertriglyceridemic rats as a prediabetic model.
  • Administered liraglutide (0.2 mg/kg/day subcutaneously) for 8 weeks.
  • Assessed changes in glucose tolerance, lipid metabolism, and hepatic gene expression.
  • Liraglutide improved glucose tolerance in all rat groups.
  • Female and OVX rats exhibited more significant reductions in visceral adiposity compared to males.
  • Liraglutide partially reversed ovariectomy effects on weight and glucose tolerance in OVX females.

Cite This Study

Lebertová et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf551faef96ed7f0575behttps://doi.org/10.3390/antiox15060729
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Also Consider

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  1. 1Liraglutide Prevents Hypoadiponectinemia-Induced Insulin Resistance and Alterations of Gene Expression Involved in Glucose and Lipid Metabolism2011 · 55 citations
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