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September 23, 2025European Journal of EndocrinologyOpen Access

OC30 - Effects of liraglutide and exercise on liver function in middle-aged rats

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Authors

DVDragana VlahovićSTSvetlana TrifunovićIGIvona Gizdović

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Overview

This study evaluates how liraglutide and exercise impact liver function and metabolic health in middle-aged rats, suggesting significant implications for aging.

Key Points

  • Liraglutide improved metabolic health and reduced liver oxidative stress in middle-aged rats, enhancing overall liver function.
  • Middle-aged rats treated with liraglutide showed decreased body mass and lower triglycerides compared to controls, supporting its metabolic benefits.
  • Exercise alone elevated oxidative stress levels but liraglutide mitigated this effect, highlighting its protective role during physical activity.
  • The combination of liraglutide and exercise modulated hepatic gene expression related to lipid metabolism, indicating synergistic effects.

Cite This Study

Vlahović et al. (2025) studied this question.

synapsesocial.com/papers/68d4724f31b076d99fa6accbhttps://doi.org/10.1093/ejendo/lvaf168.049
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1OC33 - Liraglutide and strength-endurance training as modulators of the stress axis in middle-aged female rats2025
  2. 2Sex-Specific and Reproductive Status-Dependent Effects of Liraglutide on Metabolic Disorders Associated with Prediabetes2026
  3. 3Elucidation of The Effects and Underlying Mechanism of Aerobic Interval Training Combined With Liraglutide On Diabetic Cardiomyopathy2022
  4. 4Changes in the Adrenal Cortex Induced by Liraglutide Treatment and Exercise in a Rat Model of Menopausal Transition2026 · 1 citations
  5. 5Liraglutide and Exercise Synergistically Attenuate Vascular Inflammation and Enhance Metabolic Insulin Action in Early Diet-induced Obesity2024