Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 15, 2026CellsOpen Access

Changes in the Adrenal Cortex Induced by Liraglutide Treatment and Exercise in a Rat Model of Menopausal Transition

View Full Paper
Ask AI
Bookmark
Share

Authors

IGIvona GizdovićBŠBranka Šošić‐JurjevićDVDragana Vlahović

Discussion

Loading...

Member takes

Overview

Randomized trial examines the impact of liraglutide and exercise on adrenal health during menopausal transition, suggesting significant effects on hormone levels.

Key Points

  • This research aims to investigate how liraglutide treatment and exercise affect the adrenal cortex during the menopausal transition in a rat model.
  • Three-month-old female rats served as controls; 16-month-old acyclic females received liraglutide, exercise, or both treatments.
  • Adrenal function and hormone levels were measured post-treatment to assess morphological and functional changes.
  • Statistical significance was determined with p-values (p ≤ 0.05).
  • Compared to young controls, the control group exhibited increased body mass and adrenal changes, including reduced weight, volume, and altered steroidogenic markers.
  • Liraglutide significantly upregulated Sf1 and Star compared to controls, indicating enhanced steroidogenesis (p ≤ 0.05).
  • Hormone analysis revealed decreased corticosterone in liraglutide-treated groups compared to controls, while aldosterone increased significantly in these groups (p ≤ 0.05).

Cite This Study

Gizdović et al. (2026) studied this question.

synapsesocial.com/papers/6a57234488b21df875480162https://doi.org/10.3390/cells15141258
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1OC33 - Liraglutide and strength-endurance training as modulators of the stress axis in middle-aged female rats2025
  2. 2OC30 - Effects of liraglutide and exercise on liver function in middle-aged rats2025
  3. 3Sex-Specific and Reproductive Status-Dependent Effects of Liraglutide on Metabolic Disorders Associated with Prediabetes2026
  4. 4Liraglutide to Improve corONary haemodynamics during Exercise streSS (LIONESS): a double-blind randomised placebo-controlled crossover trial2021 · 4 citations
  5. 5Liraglutide and Exercise Synergistically Attenuate Vascular Inflammation and Enhance Metabolic Insulin Action in Early Diet-induced Obesity2024