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January 3, 2022Open Access

Elucidation of The Effects and Underlying Mechanism of Aerobic Interval Training Combined With Liraglutide On Diabetic Cardiomyopathy

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Why the study?

This study intended to explore the hypoglycemic and cardioprotective effects of 8-week aerobic interval training combined with liraglutide and elucidate the underlying mechanisms in diabetic cardiomyopathy.

Does aerobic interval training combined with liraglutide improve cardiac function and alleviate myocardial fibrosis in a rat model of diabetic cardiomyopathy?

Population

Male Wistar rats

Comparison

Aerobic interval training plus liraglutide vs high-dose liraglutide, low-dose liraglutide, diabetic cardiomyopathy control, and normal control

Design

Randomized preclinical animal study

Follow-up

8 weeks

Authors

HCHuan CaiLZLinling ZhouJLJingqin Liu

Discussion

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Overview

Hypothesis-generating for combined training plus liraglutide in DCM; leaves open clinical translation.

Structured PICO

Does aerobic interval training combined with liraglutide improve cardiac function and alleviate myocardial fibrosis in a rat model of diabetic cardiomyopathy?

P
Population
Male Wistar rats (8 weeks old, bodyweight 250-280 g), n=50, with diabetic cardiomyopathy induced by high-fat diet and streptozotocin (STZ) injection.
I
Intervention
Aerobic interval training (AIT) on a treadmill (60 min/day) combined with low-dose liraglutide (0.2 ml/kg/day) for 8 weeks.
C
Comparator
Diabetic cardiomyopathy (DCM) control group receiving high-fat diet without treatment, and normal control (CON) group receiving ordinary feed and saline.
O
Outcome
Cardiac function (EF, FS, CO, E/A ratio, IVRT), fasting blood glucose (FBG), fasting insulin (FINs), HbA1c, total collagen content, AGEs, mRNA expression of myocardial remodeling genes (BNP, GSK3β, α-MHC, β-MHC), and GLP-1/GLP-1R protein expression after 8 weeks.surrogate

Aerobic interval training combined with liraglutide synergistically improves cardiac function, reduces blood glucose, and alleviates myocardial fibrosis in a rat model of diabetic cardiomyopathy.

Cite This Study

Cai et al. (2022) studied this question.

synapsesocial.com/papers/6a7e445a7f55e1ae3983e4b4https://doi.org/10.21203/rs.3.rs-1150327/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Liraglutide combined with HIIT preserves contractile apparatus and blunts the progression of heart failure in diabetic cardiomyopathy rats2025 · 2 citations
  2. 2The protective effects of liraglutide in reducing lipid droplets accumulation and myocardial fibrosis in diabetic cardiomyopathy2025 · 15 citations
  3. 3Liraglutide protects cardiac function in diabetic rats through the PPARα pathway2018 · 36 citations
  4. 4Protective effect of liraglutide on the myocardium of type 2 diabetic rats by inhibiting polyadenosine diphosphate-ribose polymerase-12023 · 4 citations
  5. 5Liraglutide alleviates cardiac fibrosis through inhibiting P4hα-1 expression in STZ-induced diabetic cardiomyopathy2019 · 25 citations