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February 13, 2018Bioscience ReportsOpen Access

Liraglutide prevented cardiac dysfunction in diabetic rats by activating the PPARα pathway to inhibit Dgat expression and oxidative stress.

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Why the study?

Does liraglutide improve cardiac function in a diabetic rat model?

Population

24 Sprague-Dawley rats; 18 fed high-fat diet for 4 weeks then injected with streptozotocin to create a…

Comparison

Liraglutide vs Vehicle and normal diet control

Design

Preclinical

Key result

Liraglutide prevented cardiac dysfunction in diabetic rats by activating the PPARα pathway to inhibit Dgat expression and oxidative stress.

Authors

QZQian ZhangXXXinhua XiaoJZJia Zheng

Discussion

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Member takes

Overview

Hypothesis-generating for liraglutide in diabetic cardiomyopathy; leaves open clinical translation from rat models.

Structured PICO

Does liraglutide improve cardiac function in a diabetic rat model?

P
Population
24 Sprague-Dawley rats, with diabetes induced by a high-fat diet and streptozotocin, used to evaluate the effects of liraglutide on cardiac function.
I
Intervention
Liraglutide (low dose 0.2 mg/kg/day, n=6; or high dose 0.4 mg/kg/day, n=6)
C
Comparator
Vehicle (diabetic control, n=6) and normal diet control (n=6)
O
Outcome
Left ventricular (LV) function, metabolic parameters, systolic blood pressure, heart rate, and whole genome expression of the heartsurrogate

Liraglutide attenuates cardiac dysfunction in diabetic rats via activation of the PPARα pathway.

Cite This Study

Zhang et al. (2018) studied Diabetes-induced cardiac dysfunction (n=24). Liraglutide vs. Vehicle was evaluated on Left ventricular function, metabolic parameters, and whole genome expression. Liraglutide prevented cardiac dysfunction in diabetic rats by activating the PPARα pathway to inhibit Dgat expression and oxidative stress.

synapsesocial.com/papers/6a6c0f102ef98b0efacb7b8dhttps://doi.org/10.1042/bsr20180059
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Liraglutide Attenuates Diabetic Cardiomyopathy via the ILK/PI3K/AKT/PTEN Signaling Pathway in Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus2024 · 10 citations
  2. 2Liraglutide alleviates cardiac fibrosis through inhibiting P4hα-1 expression in STZ-induced diabetic cardiomyopathy2019 · 25 citations
  3. 3Protective effect of liraglutide on the myocardium of type 2 diabetic rats by inhibiting polyadenosine diphosphate-ribose polymerase-12023 · 4 citations
  4. 4Liraglutide Ameliorates Renal Endothelial Dysfunction in Diabetic Rats Through the Inhibition of the Dll4/Notch2 Pathway2024 · 4 citations
  5. 5The protective effects of liraglutide in reducing lipid droplets accumulation and myocardial fibrosis in diabetic cardiomyopathy2025 · 15 citations