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February 12, 2021Diabetology & Metabolic SyndromeOpen Access

Liraglutide to Improve corONary haemodynamics during Exercise streSS (LIONESS): a double-blind randomised placebo-controlled crossover trial

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Why the study?

GLP-1 receptor activation may improve myocardial performance during ischaemia independent of glycaemic control, but whether prolonged activation improves exercise haemodynamics in chronic stable angina was unknown.

Does liraglutide improve exercise haemodynamics (rate pressure product and ST-segment depression) in patients with chronic stable angina and obstructive CAD?

Comparison

Liraglutide (dose-escalated to 1.8 mg daily) vs matched saline placebo

Design

Single-centre randomised double-blind placebo-controlled crossover study

Authors

AMAung MyatSRSimon RedwoodSASatpal Arri

Discussion

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Overview

GLP-1R activation does not improve exercise haemodynamics in stable angina; leaves open effects on other ischaemic endpoints or populations.

Structured PICO

Does liraglutide improve exercise haemodynamics (rate pressure product and ST-segment depression) in patients with chronic stable angina and obstructive CAD?

P
Population
22 patients (21 without diabetes) with chronic stable angina, angiographic evidence of obstructive coronary artery disease (CAD), and an abnormal baseline exercise tolerance test demonstrating > 0.1 mV of planar or downsloping ST-segment depression.
I
Intervention
Liraglutide daily injection (0.6 mg for 1 week, followed by 1.2 mg for 1 week, then 1.8 mg for 1 week).
C
Comparator
Visually and temporally matched daily saline injections (placebo).
O
Outcome
Co-primary endpoints: rate pressure product (RPP) at 0.1 mV ST-segment depression (STD) and magnitude of STD at peak exercise.surrogate

Short-term liraglutide therapy does not improve exercise tolerance or coronary hemodynamics in patients with stable obstructive CAD, despite favorable effects on weight and lipids.

Cite This Study

Myat et al. (2021) studied this question.

synapsesocial.com/papers/6a7019d478a11c550e09e87bhttps://doi.org/10.1186/s13098-021-00635-6
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Also Consider

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  3. 3Effect of Liraglutide on Cardiovascular Events in Patients With Type 2 Diabetes Mellitus and Polyvascular Disease2018 · 108 citations
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