April 30, 2019Cardiovascular DiabetologyOpen Access

Effect of liraglutide on cardiac function in patients with type 2 diabetes mellitus: randomized placebo-controlled trial

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Why the study?

Liraglutide is an antidiabetic agent with cardioprotective effects, but its efficacy to improve diabetic cardiomyopathy in patients with type 2 diabetes mellitus without cardiovascular disease required testing.

Does liraglutide improve cardiac function in patients with type 2 diabetes mellitus without cardiovascular disease?

Population

Patients with DM2 without cardiovascular disease (23 randomized to liraglutide, 26 to placebo)

Comparison

Liraglutide 1.8 mg/day vs placebo

Design

Double-blind randomized placebo-controlled trial

Follow-up

26 weeks

Authors

MBMaurice B. BizinoLeiden University Medical Center IJIngrid M. JazetLeiden University Medical Center JWJos J.M. WestenbergCardiac Imaging

Discussion

Member takes

Implication

Liraglutide unloads the LV via reduced diastolic filling in asymptomatic DM2; extends surrogate evidence but leaves open effects on cardiomyopathy progression.

Structured PICO

Does liraglutide improve cardiac function in patients with type 2 diabetes mellitus without cardiovascular disease?

Population

n=49 patients with diabetes mellitus type 2 (DM2) without cardiovascular disease

Intervention

Liraglutide 1.8 mg/day for 26 weeks

Comparator

Placebo

Outcome

LV diastolic function (early (E) and late (A) transmitral peak flow rate, E/A ratio, early deceleration peak (Edec), early peak mitral annular septal tissue velocity (Ea) and estimated LV filling pressure (E/Ea)) and systolic function (stroke volume, ejection fraction, cardiac output, cardiac index and peak ejection rate) assessed with CMRsurrogate

Liraglutide reduces early LV diastolic filling and LV filling pressure in patients with type 2 diabetes without cardiovascular disease, suggesting a potential unloading effect on the left ventricle.

Cite This Study

Bizino et al. (2019) studied this question.

synapsesocial.com/papers/6a8a832f6fc170cbc2fbf605 https://doi.org/10.1186/s12933-019-0857-6

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Implication

Liraglutide unloads the LV via reduced diastolic filling in asymptomatic DM2; extends surrogate evidence but leaves open effects on cardiomyopathy progression.

Effect of liraglutide on cardiac function in patients with type 2 diabetes mellitus: randomized placebo-controlled trial

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of liraglutide on cardiac function in patients with type 2 diabetes mellitus: randomized placebo-controlled trial

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider