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June 13, 2026American Journal of Rhinology and Allergy

The Effect of Chitosan-Based Dressings on Postoperative Outcomes in Patients Undergoing Endoscopic Sinus Surgery: A Systematic Review and Meta-Analysis

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Authors

AAAhmed K. AlmukhlifiAAAbdullah O. AlmutairiLALara S. Alansari

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Overview

Systematic review assesses chitosan-based therapies' effects on postoperative outcomes, indicating benefits in ostial preservation and infection reduction.

Key Points

  • This review aims to evaluate the effectiveness of chitosan-based therapies following endoscopic sinus surgery.
  • Included randomized trials comparing chitosan-based products with no treatment, standard care, or active comparators.
  • Assessed outcomes focused on ostial area preservation and wound-healing parameters.
  • Utilized random-effects models for analysis of weighted mean differences and risk ratios.
  • Chitosan-based products improved ostial area preservation compared to no treatment (WMD = 18.3%, 95% CI: 11.6-25.1%; P < .0001).
  • Reduced adhesions (RR = 0.36, P = .006) and crusting (RR = 0.67, P = .009) was noted, with significance dependent on comparator type.
  • Chitosan-based products decreased infection rates versus no treatment (RR = 0.39, P = .002), but not versus active comparators.

Cite This Study

Almukhlifi et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf551faef96ed7f057616https://doi.org/10.1177/19458924261457275
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