Dapagliflozin-Induced Dermatological Condition: Sweet’s Syndrome

Sweet's syndrome, or acute febrile neutrophilic dermatosis, is an uncommon inflammatory condition characterized by the sudden onset of fever, neutrophilia, and painful erythematous skin lesions. We present the case of a 54-year-old female who was started on anti-glycemic medication for glycemic control and developed tender erythematous plaques and nodules over the upper limbs. Comprehensive evaluation excluded infectious, autoimmune, endocrine, and neoplastic causes. Skin biopsy demonstrated a dense neutrophilic infiltrate without evidence of vasculitis, supporting the diagnosis of Sweet’s syndrome. The patient was managed with systemic corticosteroids, resulting in clinical improvement. This case emphasizes the importance of recognizing Sweet’s syndrome in the context of drug-induced etiology, as well as the role of timely dermatologic assessment and metabolic stabilization in achieving favorable outcomes.