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June 13, 2026International Journal of Molecular SciencesOpen Access

Immunohistochemical Analysis of pH-Sensitive TRPV5 in Common Skin Tumors

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Authors

SWSophia Victoria WeißJHJudith HeiderDNDennis Niebel

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Overview

Immunohistochemical analysis reveals varying TRPV5 expression in common skin tumors, suggesting its potential as a differentiation marker.

Key Points

  • This study aims to analyze the expression of the TRPV5 ion channel in various common skin tumors to understand its role in tumor biology.
  • Conducted immunohistochemical analysis of TRPV5 in basal cell carcinoma, squamous cell carcinoma, malignant melanoma, and melanocytic nevi.
  • Compared TRPV5 expression levels across the different tumor types.
  • Significantly lower expression of TRPV5 in basal cell carcinoma compared to squamous cell carcinoma, malignant melanoma, and melanocytic nevi.
  • Less than 50% of basal cell carcinomas tested positive for TRPV5, while squamous cell carcinomas, malignant melanomas, and melanocytic nevi exhibited high positive staining.

Cite This Study

Weiß et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf5aefaef96ed7f0579b1https://doi.org/10.3390/ijms27125287
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