What question did this study set out to answer?

This study estimates the prevalence and severity of posttransfusion iron overload and its association with systemic complications among hemoglobinopathy patients.

June 13, 2026Journal of Primary Care SpecialtiesOpen Access

Posttransfusion Iron Overload and Its Systemic Complications among Transfusion-dependent Hemoglobinopathy Patients in Central India

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Authors

RKRudraksh KesharwaniChhattisgarh Dental College & Research Institute RARitika AgarkarGovernment Medical College SNShubhangi NagpalUniversity College Hospital

Discussion

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Implication

Randomized trial evaluates posttransfusion iron overload and systemic complications in hemoglobinopathy patients, suggesting urgent need for monitoring.

Key Points

This study estimates the prevalence and severity of posttransfusion iron overload and its association with systemic complications among hemoglobinopathy patients.
Conducted a hospital-based analytical cross-sectional study over 2 years with 456 transfusion-dependent patients.
Defined iron overload using serum ferritin levels and assessed complications through clinical and laboratory parameters.
Applied multivariable logistic regression to identify factors linked to systemic complications.
Iron overload was observed in 93.6% of patients, with 69.0% having moderate-to-severe overload.
Patients with severe overload showed significantly higher rates of hepatic dysfunction (35.5%) and diabetes mellitus (10.3%).
Median direct medical costs rose from INR 32,000 to INR 78,000 with increasing iron overload severity.

Cite This Study

Kesharwani et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf5aefaef96ed7f057a45 https://doi.org/10.4103/jopcs.jopcs_11_26

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June 13, 2026Journal of Primary Care SpecialtiesOpen Access

Posttransfusion Iron Overload and Its Systemic Complications among Transfusion-dependent Hemoglobinopathy Patients in Central India

View Full Paper

Ask AI

Bookmark

Authors

RKRudraksh KesharwaniChhattisgarh Dental College & Research Institute RARitika AgarkarGovernment Medical College SNShubhangi NagpalUniversity College Hospital

Discussion

Member takes

Implication

Randomized trial evaluates posttransfusion iron overload and systemic complications in hemoglobinopathy patients, suggesting urgent need for monitoring.

Key Points

This study estimates the prevalence and severity of posttransfusion iron overload and its association with systemic complications among hemoglobinopathy patients.
Conducted a hospital-based analytical cross-sectional study over 2 years with 456 transfusion-dependent patients.
Defined iron overload using serum ferritin levels and assessed complications through clinical and laboratory parameters.
Applied multivariable logistic regression to identify factors linked to systemic complications.
Iron overload was observed in 93.6% of patients, with 69.0% having moderate-to-severe overload.
Patients with severe overload showed significantly higher rates of hepatic dysfunction (35.5%) and diabetes mellitus (10.3%).
Median direct medical costs rose from INR 32,000 to INR 78,000 with increasing iron overload severity.

Cite This Study

Kesharwani et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf5aefaef96ed7f057a45 https://doi.org/10.4103/jopcs.jopcs_11_26

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