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December 8, 2025Blood

Iron overload is prevalent, likely underdiagnosed and undertreated in sickle cell disease: A real-world report from the ASH research collaborative

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Authors

SWSam WaltersTWTed WunJLJane A. Little

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Overview

Cross-sectional analysis reveals high prevalence of iron overload in sickle cell disease, highlighting gaps in screening and diagnosis.

Key Points

  • To determine the prevalence, screening, diagnosis, and management of iron overload in sickle cell disease.
  • Conducted a cross-sectional analysis using data from the ASH Research Collaborative Data Hub.
  • Included adults with confirmed sickle cell disease and at least one year of follow-up.
  • Used ferritin values as a surrogate for liver iron concentration to assess iron overload.
  • 10% of individuals were classified as probable iron overload, 8.8% as possible, and 81% as unlikely.
  • Individuals with HbSS genotype showed the highest prevalence of likely iron overload.
  • More than half of those with probable iron overload were not prescribed chelation.

Cite This Study

Walters et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e543https://doi.org/10.1182/blood-2025-2667
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The burden of iron overload in sickle cell disease: insights from South Carolina, USA.2025 · 1 citations
  2. 2Posttransfusion Iron Overload and Its Systemic Complications among Transfusion-dependent Hemoglobinopathy Patients in Central India2026
  3. 3Prevalence and timing of iron deficiency among youth with sickle cell disease receiving chronic transfusions2025
  4. 4Prevalence of iron deficiency among youth with sickle cell disease2025
  5. 5Non-pharmacological interventions as adjuncts to iron chelation therapy in sickle cell disease on chronic transfusion: a scoping review with evidence gap mapping2026