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December 19, 2025Investigación ClínicaOpen Access

The burden of iron overload in sickle cell disease: insights from South Carolina, USA.

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Authors

GVGilberto VizcaínoCAChristina M. AbramsCFCaroline Foster

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Overview

Cohort study reveals iron overload impacts stroke and pulmonary hypertension in sickle cell disease patients, indicating need for better chelation therapy.

Key Points

  • This research aims to assess the relationship between iron overload and comorbidities in sickle cell disease patients.
  • Cohort of 245 adult sickle cell disease patients studied at Medical University of South Carolina.
  • Medical records were used to collect information on patients.
  • Statistical analysis examined correlations and odds ratios with 95% confidence intervals.
  • Identified 85 participants with iron overload, representing 34.7% of the cohort.
  • Significant associations found between iron overload and stroke, pulmonary hypertension, acute chest syndrome, and deep vein thrombosis.
  • Strong correlation observed between liver iron concentration and ferritin levels.

Cite This Study

Vizcaíno et al. (2025) studied this question.

synapsesocial.com/papers/69449a892f0218eca9508370https://doi.org/10.54817/ic.v66n4a03
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Iron overload is prevalent, likely underdiagnosed and undertreated in sickle cell disease: A real-world report from the ASH research collaborative2025 · 1 citations
  2. 2Non-pharmacological interventions as adjuncts to iron chelation therapy in sickle cell disease on chronic transfusion: a scoping review with evidence gap mapping2026
  3. 3Assessing Liver and Iron Markers in Steady State Pediatric SCD Patients to Ascertain the Hepatic Consequences of Hemotransfusion: A Case‐Control Study in Ghana2026
  4. 4Iron stores in steady‐state sickle cell disease children accessing care at a sickle cell disease clinic in Kumasi, Ghana: A cross‐sectional study2022 · 13 citations
  5. 5Posttransfusion Iron Overload and Its Systemic Complications among Transfusion-dependent Hemoglobinopathy Patients in Central India2026