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December 8, 2025Blood

Prevalence of iron deficiency among youth with sickle cell disease

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Authors

BKBrett KlamerSCSapuni S. ChandrasenaHRHollie M. Reeves

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Overview

This study finds 41% of youth with sickle cell disease have iron deficiency, indicating a link with anemia and cognitive deficits.

Key Points

  • The research aims to determine the prevalence of iron deficiency among youth with sickle cell disease and explore its associations with anemia.
  • Identified youth with sickle cell disease from clinical database at Nationwide Children's Hospital.
  • Collected demographic, laboratory, and clinical data, including ferritin levels.
  • Conducted linear regression to analyze relationships between iron deficiency and hemoglobin, as well as mean corpuscular volume.
  • Out of 550 youth, 40% had ferritin levels checked and 52% had levels <100 ng/mL.
  • 41% had iron deficiency, with mean hemoglobin of 10.2 g/dL in the ID group versus 9.6 g/dL in the possible ID group.
  • Mean corpuscular volume was lower in the ID group (69 fL) compared to possible ID group (81 fL).

Cite This Study

Klamer et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2b4https://doi.org/10.1182/blood-2025-6467
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevalence and timing of iron deficiency among youth with sickle cell disease receiving chronic transfusions2025
  2. 2Red cell indices in adolescents with iron deficiency and heavy menstrual bleeding2025
  3. 3Iron overload is prevalent, likely underdiagnosed and undertreated in sickle cell disease: A real-world report from the ASH research collaborative2025 · 1 citations
  4. 4Iron Profile in Patients with Congenital Cyanotic Heart Disease2024
  5. 5Iron deficiency in children with cyanotic congenital heart disease: prevalence and clinical implications2025