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December 8, 2025BloodOpen Access

Prevalence and timing of iron deficiency among youth with sickle cell disease receiving chronic transfusions

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Authors

ADAnna DiNardoAYAnyssa YoungAJAmanda Jacobson‐Kelly

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Overview

Retrospective analysis shows 45% of youth with sickle cell disease on chronic transfusions have iron deficiency, suggesting monitoring is crucial.

Key Points

  • To determine the prevalence and timing of iron deficiency among youth with sickle cell disease receiving chronic transfusions.
  • Single-center, retrospective chart review
  • Analysis of youth ages 6 months-21 years with sickle cell disease
  • Routine ferritin monitoring every three months during chronic transfusions
  • Demographic and clinical data abstracted from electronic medical records
  • Identified 60 eligible youth; 27 (45%) had either iron deficiency or possible iron deficiency.
  • 22% of affected youth were 8-12 years, 48% were 13-17 years, and 30% were 18-21 years.
  • All youth with iron deficiency and most with possible iron deficiency had ferritin levels <100 ng/mL within two years of initiating chronic transfusions.

Cite This Study

DiNardo et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236ddcfhttps://doi.org/10.1182/blood-2025-2905
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevalence of iron deficiency among youth with sickle cell disease2025
  2. 2Iron overload is prevalent, likely underdiagnosed and undertreated in sickle cell disease: A real-world report from the ASH research collaborative2025 · 1 citations
  3. 3Prevalence and treatment of iron deficiency in children with cystic fibrosis2025
  4. 4Red cell indices in adolescents with iron deficiency and heavy menstrual bleeding2025
  5. 5Assessing Liver and Iron Markers in Steady State Pediatric SCD Patients to Ascertain the Hepatic Consequences of Hemotransfusion: A Case‐Control Study in Ghana2026