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August 5, 2026Annals of HematologyOpen Access

Non-pharmacological interventions as adjuncts to iron chelation therapy in sickle cell disease on chronic transfusion: a scoping review with evidence gap mapping

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Authors

SFShihshuan FangLandseed HospitalSCShenghan ChenFuzhou University

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Implication

Scoping review evaluates non-pharmacological adjuncts to improve outcomes in sickle cell disease patients on transfusion therapy, revealing evidence gaps.

Key Points

  • This review aims to examine the role of non-pharmacological interventions alongside iron chelation therapy in patients with sickle cell disease undergoing chronic transfusion.
  • Conducted a scoping review and evidence gap mapping per PRISMA-ScR guidelines.
  • Performed systematic searches in PubMed, Embase, and Cochrane Library until May 2026 for relevant studies.
  • Identified and categorized 14 studies involving 642 participants focusing on various non-pharmacological interventions.
  • Revealed a concentration of studies on short-term adherence and quality of life.
  • Noted a lack of long-term data on objective iron parameters like liver iron concentration.
  • Quality of evidence overall was low to moderate, impacted by small sample sizes and heterogeneity.

Cite This Study

Fang et al. (2026) studied this question.

synapsesocial.com/papers/6a72e84e226790f3706580a6https://doi.org/10.1007/s00277-026-07218-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia2016 · 37 citations
  2. 2Iron overload is prevalent, likely underdiagnosed and undertreated in sickle cell disease: A real-world report from the ASH research collaborative2025 · 1 citations
  3. 3Iron Chelation Therapy in Iron Overload Disorders: A Systematic Review with Narrative Synthesis of Bioenergetic Dysfunction, Oxidative Stress, and Biomarker-Guided Management2026
  4. 4The burden of iron overload in sickle cell disease: insights from South Carolina, USA.2025 · 1 citations
  5. 5Safety and Efficacy of Iron Chelators in Patients With Chronic Kidney Disease: A Systematic Review and Meta‐Analysis2026