Research Progress in Biomedical Materials

Biomedical materials, which are engineered to interact safely and effectively with biological systems, serve as the foundation of modern medicine. They facilitate precise diagnostics, targeted therapies, tissue regeneration, and the functional restoration of damaged organs and tissues. Propelled by advancements in materials science, nanotechnology, and clinical understanding, this field is rapidly evolving from passive implants to intelligent, responsive, and bioactive systems. This review summarize recent breakthroughs in four crucial domains: hard-tissue repair, dynamic wound healing, spatiotemporally controlled drug delivery, and advanced surface engineering. This article rigorously assesses the persistent translational barriers, particularly the disparity between in vitro biocompatibility assays and clinical performance, the scalability constraints in manufacturing, and the fragmentation in regulatory frameworks and international standards. By connecting fundamental innovation with real-world clinical needs, this review functions as both a strategic reference for researchers and a practical resource for clinicians exploring the next generation of biomedical materials.