What question did this study set out to answer?

The study aimed to assess the feasibility and effects of leucine supplementation combined with exercise on muscle health in end-stage kidney disease patients undergoing hemodialysis.

June 13, 2026Kidney Research and Clinical PracticeOpen Access

Combined leucine supplementation and exercise to counteract sarcopenia in patients with end-stage kidney disease undergoing maintenance hemodialysis: a single-center randomized pilot study

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Authors

JLJieun LeeChungnam National University HLHo Yeop LeeChungnam National University HNHa Thi NgaChungnam National University

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Implication

Randomized trial evaluates leucine and exercise effects on muscle function in ESKD patients, suggesting potential benefits.

Key Points

The study aimed to assess the feasibility and effects of leucine supplementation combined with exercise on muscle health in end-stage kidney disease patients undergoing hemodialysis.
Single-center randomized pilot trial with 24 patients undergoing maintenance hemodialysis assigned to exercise alone or exercise plus 6 g/day leucine for 12 weeks.
Primary outcome was change in handgrip strength; secondary outcomes included physical performance measures and biochemical markers.
The intervention group exhibited higher responder rates for handgrip strength (p<0.05) and gait speed compared to the control group.
Skeletal muscle index saw modest increases in the intervention group.
Biochemical markers, such as total protein and blood urea nitrogen, showed directional increases in the intervention group.

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf688faef96ed7f05839c https://doi.org/10.23876/j.krcp.25.433

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Combined leucine supplementation and exercise to counteract sarcopenia in patients with end-stage kidney disease undergoing maintenance hemodialysis: a single-center randomized pilot study

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Key Points

Cite This Study

Combined leucine supplementation and exercise to counteract sarcopenia in patients with end-stage kidney disease undergoing maintenance hemodialysis: a single-center randomized pilot study

Discussion

Member takes

Implication

Key Points

Cite This Study

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