What is the clinical evidence from this study?

Study design: Other. Population: Heart failure with reduced ejection fraction (HFrEF) and sarcopenia (n=60). Intervention: Essential amino acid supplementation. Primary outcome: Changes in Global Longitudinal Strain (GLS) (p=<0.0001).

What question did this study set out to answer?

To evaluate the early effects of essential amino acid supplementation on cardiac and muscle performance in elderly patients with heart failure and sarcopenia.

February 6, 2026European Heart Journal

Early effect of essential aminoacid supplementation on cardiac performance in elderly patients with heart failure and sarcopenia

Q: What are the key findings of this study?

Essential amino acid supplementation for 6 months in elderly patients with HFrEF and sarcopenia significantly improved Global Longitudinal Strain (from -8.5% to -11.9%, P<0.0001).

Q: What question did this study set out to answer?

To evaluate the early effects of essential amino acid supplementation on cardiac and muscle performance in elderly patients with heart failure and sarcopenia.

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Key result

Essential amino acid supplementation is linked to ~40% better GLS in sarcopenic HFrEF.

P<0.0001
n=60

Why the study?

Does essential amino acid supplementation improve cardiac and muscular performance in elderly patients with HFrEF and sarcopenia?

Population

60 Caucasian patients with heart failure with reduced ejection fraction, NYHA class II and class III, and…

Design

Cohort

Follow-up

6 months

Authors

GAG ArmentaroMagna Graecia University PLPasquale LoiaconoMagna Graecia University MSM R ScarcelliMagna Graecia University

Discussion

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Implication

Early effects of essential amino acid supplementation improve cardiac and muscle performance in heart failure and sarcopenia patients, suggesting potential therapeutic benefits.

Key Points

To evaluate the early effects of essential amino acid supplementation on cardiac and muscle performance in elderly patients with heart failure and sarcopenia.
Evaluated 60 elderly patients with heart failure and sarcopenia
Supplemented with essential amino acids (L-Leucine, L-Isoleucine, L-Valine) twice daily
Utilized linear regression and multivariate regression models to analyze data
Clinical symptoms improved significantly (KCCQ-CS increased from 60.9 to 64.6 points, p=0.001)
Muscle performance enhanced (Hand grip strength increased from 18.9 to 21.5 kg, p<0.0001)
Echocardiographic parameters improved (Left Ventricular Ejection Fraction increased from 34.3% to 35.8%, p<0.0001)
Significant reductions in oxidative stress biomarkers (Nox-2 decreased from 0.7 to 0.5 nmol/L, p<0.0001)

Structured PICO

Does essential amino acid supplementation improve cardiac and muscular performance in elderly patients with HFrEF and sarcopenia?

Population

60 elderly Caucasian patients (mean age 80.1 years, 22% female) with HFrEF and sarcopenia, followed for 6 months.

Intervention

Essential amino acid preparations (L-Leucine 2500mg, L-Isoleucine 1250mg, L-Valine 1250mg) twice daily added to optimal medical therapy for 6 months.

Outcome

Changes in Global Longitudinal Strain (GLS) between baseline and follow-up at 6 monthssurrogate

Main Result

Absolute Event Rate: -11.9% vs -8.5%

p-value: p=<0.0001

Cite This Study

Armentaro et al. (2025) studied Heart failure with reduced ejection fraction (HFrEF) and sarcopenia (n=60). Essential amino acid supplementation was evaluated on Changes in Global Longitudinal Strain (GLS) (p=<0.0001). Essential amino acid supplementation for 6 months in elderly patients with HFrEF and sarcopenia significantly improved Global Longitudinal Strain (from -8.5% to -11.9%, P<0.0001).

synapsesocial.com/papers/698585cb8f7c464f2300981b https://doi.org/10.1093/eurheartj/ehaf784.1400

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Implication

Early effects of essential amino acid supplementation improve cardiac and muscle performance in heart failure and sarcopenia patients, suggesting potential therapeutic benefits.

Early effect of essential aminoacid supplementation on cardiac performance in elderly patients with heart failure and sarcopenia

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Early effect of essential aminoacid supplementation on cardiac performance in elderly patients with heart failure and sarcopenia

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

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