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January 1, 2014Clinical Medicine Insights CardiologyOpen Access

Effects of Oral Amino Acid Supplements on Functional Capacity in Patients with Chronic Heart Failure

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Key result

Oral amino acid supplementation in chronic HF is linked to ~14% higher peak VO2.

  • P=0.008
  • n=13

Why the study?

Amino acid availability is reduced in patients with heart failure, leading to metabolic abnormalities and reduced functional capacity, but the effects of oral amino acid supplementation on exercise tolerance and quality of life are unclear.

Does oral amino acid supplementation improve exercise tolerance in patients with chronic stable heart failure?

Population

13 patients with chronic stable HF, NYHA class II/III, EF <45%

Comparison

Oral supplementation with essential and semi-essential amino acids for three months vs baseline

Design

Cohort study

Follow-up

Three months

Authors

CLCarlo LombardiVCValentina CarubelliVLValentina Lazzarini

Discussion

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Member takes

Overview

Hypothesis-generating for amino acid supplementation in chronic HF; randomized trials needed before clinical adoption.

Structured PICO

Does oral amino acid supplementation improve exercise tolerance in patients with chronic stable heart failure?

P
Population
13 patients with stable chronic heart failure (NYHA class II/III, EF <45%) on optimal therapy, mean age 59 years, treated with oral amino acids for 3 months.
I
Intervention
Oral supplementation with essential and semi-essential amino acids for three months
O
Outcome
Exercise tolerance evaluated by cardiopulmonary stress test (peak VO2 and VO2 at anaerobic threshold) and six minutes walking test (6MWT) at three monthssurrogate

Main Result

Absolute Event Rate: 16.8% vs 14.8%

p-value: p=0.008

Oral amino acid supplementation for three months in patients with chronic stable heart failure improved exercise tolerance but did not significantly change quality of life.

Cite This Study

Lombardi et al. (2014) studied chronic stable heart failure (n=13). Oral amino acid supplements vs. Baseline was evaluated on exercise tolerance (peak VO2) (p=0.008). Oral amino acid supplementation for 3 months in chronic heart failure significantly improved peak VO2 (14.8 vs 16.8 mL/min/kg; P=0.008) and 6MWT distance (439.1 vs 474.2 m; P=0.006).

synapsesocial.com/papers/6aa90515f153b06b0dd91d5fhttps://doi.org/10.4137/cmc.s14016
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of an oral amino acid–containing formulation on clinical and functional outcomes in patients with and without heart failure undergoing cardiac rehabilitation program: a pilot study2026
  2. 2Early Effect of Supplementation with Essential Amino Acids on Cardiac Performance in Elderly Patients with Heart Failure and Sarcopenia2025 · 3 citations
  3. 3Oral Amino Acid Administration Decreases Oxidative Stress and Improves Brachial Reactivity in Elderly Individuals2005 · 6 citations
  4. 4Aldosterone antagonists improve ejection fraction and functional capacity independently of functional class: a meta-analysis of randomised controlled trials2012 · 29 citations
  5. 5The effect of aerobic exercise on muscle tissue in patients with severe heart failure and normal body weight2020 · 2 citations