Correlation Between Quantitative Pupillometry and Other Markers for Neuroprognostication of Comatose Patients After Cardiac Arrest: A Bicentric Study

Sarah Benghanem; Jan Novy; A C Cariou; Nawfel Ben-Hamouda; Andréa O. Rossetti

doi:10.1097/ccm.0000000000007210

June 11, 2026Critical Care Medicine

Correlation Between Quantitative Pupillometry and Other Markers for Neuroprognostication of Comatose Patients After Cardiac Arrest: A Bicentric Study

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Key Points

This research investigates the prognostic value of quantitative pupillometry in predicting outcomes for comatose patients after cardiac arrest, alongside other clinical indicators.
Bicentric analysis of prospective registries from two hospitals in Switzerland and France.
Patients included were comatose adults, with pupillometry data collected within 48-72 hours post-cardiac arrest.
Prognostic correlations between quantitative pupillometry and markers such as EEG, SSEPs, and serum neuron-specific enolase were assessed.
Minimum qPLR below 2% correlated with poor outcomes (96.4% specificity, 23.6% sensitivity).
High specificity found for NPi less than or equal to 2 correlating with poor outcome (99% specificity, 34% sensitivity).
Patients showing qPLR greater than 9.5% (83.2% specificity, 31.1% sensitivity) correlated with good outcome.

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Implication

Bicentric study assesses relationships of quantitative pupillometry with neuroprognostic markers in comatose patients, indicating predictive values for outcomes.

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Cite This Study

Benghanem et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf6d7faef96ed7f058768 https://doi.org/10.1097/ccm.0000000000007210

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Correlation Between Quantitative Pupillometry and Other Markers for Neuroprognostication of Comatose Patients After Cardiac Arrest: A Bicentric Study

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Correlation Between Quantitative Pupillometry and Other Markers for Neuroprognostication of Comatose Patients After Cardiac Arrest: A Bicentric Study

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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