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June 13, 2026Applied Microbiology and BiotechnologyOpen Access

A constitutive promoter toolbox for tunable gene expression in Acinetobacter baumannii

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Authors

JZJing ZhangDLDaiyu LiHWHongtao Wang

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Overview

Randomized trial shows tunable gene expression in Acinetobacter baumannii, indicating potential for further functional studies.

Key Points

  • This research aims to develop a set of constitutive promoters for controlling gene expression in Acinetobacter baumannii.
  • Developed an eGFP-based reporter system for promoter characterization.
  • Tested 25 candidate promoters selected from highly expressed genes based on transcriptomic data.
  • Constructed 19 constitutive expression vectors for gene expression studies.
  • 19 out of 25 tested promoters showed detectable activity with varying expression strengths.
  • Quantitative analyses confirmed both transcriptional and translational outputs across growth phases.
  • Overexpression of the strAB gene cluster resulted in reduced susceptibility to streptomycin.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf701faef96ed7f058995https://doi.org/10.1007/s00253-026-13894-y
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