What question did this study set out to answer?

This study aims to compare the oncologic outcomes of laparoscopic versus open surgery specifically in early-onset low rectal cancer patients.

June 13, 2026World Journal of Surgery

Comparative Oncologic Outcomes of Laparoscopic versus Open Surgery for Early‐Onset Low Rectal Cancer: 3‐Year Results From the LASRE Trial

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Authors

YSY SunUnion Hospital ZXZhenyu XuFujian Medical University XWXiaojie WangFujian Medical University

Discussion

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Implication

Randomized trial compares oncologic outcomes of laparoscopic versus open surgery in early-onset low rectal cancer, suggesting non-inferiority of laparoscopic resection.

Key Points

This study aims to compare the oncologic outcomes of laparoscopic versus open surgery specifically in early-onset low rectal cancer patients.
Post-hoc analysis from the LASRE trial involving 240 early-onset and 799 late-onset low rectal cancer patients.
Patients were randomly assigned to open or laparoscopic resection for outcomes evaluation.
Primary endpoints included overall survival and disease-free survival at three years.
3-year overall survival was 91.3% for laparoscopic and 95.5% for open surgery (p = 0.270).
3-year disease-free survival was 78.6% for laparoscopic and 76.1% for open surgery (p = 0.657).
No significant differences in oncologic outcomes were observed between laparoscopic and open surgery groups.

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf776faef96ed7f058baf https://doi.org/10.1002/wjs.70450

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June 13, 2026World Journal of Surgery

Comparative Oncologic Outcomes of Laparoscopic versus Open Surgery for Early‐Onset Low Rectal Cancer: 3‐Year Results From the LASRE Trial

View Full Paper

Ask AI

Bookmark

Authors

YSY SunUnion Hospital ZXZhenyu XuFujian Medical University XWXiaojie WangFujian Medical University

Discussion

Member takes

Implication

Randomized trial compares oncologic outcomes of laparoscopic versus open surgery in early-onset low rectal cancer, suggesting non-inferiority of laparoscopic resection.

Key Points

This study aims to compare the oncologic outcomes of laparoscopic versus open surgery specifically in early-onset low rectal cancer patients.
Post-hoc analysis from the LASRE trial involving 240 early-onset and 799 late-onset low rectal cancer patients.
Patients were randomly assigned to open or laparoscopic resection for outcomes evaluation.
Primary endpoints included overall survival and disease-free survival at three years.
3-year overall survival was 91.3% for laparoscopic and 95.5% for open surgery (p = 0.270).
3-year disease-free survival was 78.6% for laparoscopic and 76.1% for open surgery (p = 0.657).
No significant differences in oncologic outcomes were observed between laparoscopic and open surgery groups.

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf776faef96ed7f058baf https://doi.org/10.1002/wjs.70450

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