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June 14, 2026Transplant InternationalOpen Access

Impact of pre-transplantation exposure to immunosuppressive agents on lung transplant outcomes in interstitial lung disease

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Authors

KTKarim TazibetVBVincent BunelHMH Mal

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Overview

Randomized trial demonstrates poorer outcomes in lung transplant recipients with prior immunosuppressive exposure, suggesting careful pre-transplant management.

Key Points

  • This research investigates how prior exposure to immunosuppressive agents affects outcomes in lung transplant recipients with interstitial lung disease.
  • Retrospective analysis of adults who underwent lung transplantation for interstitial lung disease between April 2011 and June 2024.
  • Comparison of outcomes between patients receiving immunosuppressive agents within one year before transplantation and those who did not.
  • Systemic steroids exposure was adjusted during the analysis.
  • Patients exposed to immunosuppressive agents had a 12-month retransplantation-free survival of 62% compared to 80% for those not exposed (HR 1.99, 95% CI [1.11–3.56], p = 0.022).
  • Immunosuppressive agent exposure increased the odds of grade 3 primary graft dysfunction (OR 3.20, 95% CI [1.42–7.45], p = 0.005).
  • Incidence of pneumonia episodes in the first 6 months was higher for exposed patients (median 2 vs. 1, p = 0.001).

Cite This Study

Tazibet et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4429b1cc60ccdea8a0f6https://doi.org/10.3389/ti.2026.16549
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Also Consider

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  1. 1Mycophenolate and Azathioprine in Fibrotic Interstitial Lung Disease2026 · 1 citations
  2. 2Retrospective analysis of patients with interstitial lung disease on lung-transplantation waiting-list2014
  3. 3Lung transplant outcomes in myositis, systemic sclerosis and idiopathic pulmonary fibrosis: a multicenter retrospective analysis2026 · 2 citations
  4. 4C105-09 No Safe Subtype: Survival After Acute Respiratory Failure in Interstitial Lung Disease2026
  5. 5Dual Impacts of Lung Transplantation on the Recovery and Comorbidity of Interstitial Lung Diseases: A Longitudinal Assessment of the Benefits and Burden2025