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June 14, 2026Frontiers in MedicineOpen Access

Baseline predictors of visual response and treatment burden after ranibizumab therapy in macular edema secondary to retinal vein occlusion

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Authors

XLXudong LiAnyang Eye HospitalLYLan YangAnyang Eye HospitalHLHe LongAnyang Eye Hospital

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Overview

Retrospective study identifies predictors of visual response in patients with RVO-ME, indicating implications for treatment strategy.

Key Points

  • This research aimed to identify baseline predictors of visual response and treatment burden in eyes with macular edema due to retinal vein occlusion treated with ranibizumab.
  • Retrospective observational study involving 80 eyes from 80 patients with RVO-ME
  • Collected baseline clinical characteristics, OCT biomarkers, and hematologic inflammatory indices
  • Evaluated visual acuity using ETDRS letter scores and assessed treatment burden through injection frequency
  • Mean gain of 21.47 ETDRS letters observed, with 26.3% of eyes showing poor functional response
  • CRVO significantly associated with poorer visual outcomes compared to BRVO (OR 6.81, p = 0.033) and higher baseline ETDRS letter scores (OR 1.85, p = 0.005)
  • Hypertension was associated with better responses (OR 0.13, p = 0.008) while OCT biomarkers showed limited associations with visual gain

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a2e44a3b1cc60ccdea8a24dhttps://doi.org/10.3389/fmed.2026.1856268
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