Key result
Structural and immunogenetic analyses reveal conserved signatures for orthomarburgvirus GP2 wing recognition.
Why the study?
The orthomarburgvirus GP2 wing region is a target for protective antibodies but was structurally undefined, and antibody recognition was poorly understood.
The study defines conserved immunogenetic and structural features for broad antibody recognition of the orthomarburgvirus GP2 wing, informing the development of vaccines and antibody countermeasures.
Answers are grounded in this paper and cite their sources.
Defines conserved GP2 wing epitope for broad antibodies; leaves open protection and vaccine translation.
Orthomarburgviruses are the etiological agents of human Marburg virus disease, with case fatality rates reaching up to 90%. Of the limited known targets for protective antibodies on the orthomarburgvirus surface glycoprotein (GP), the GP2 wing region is undefined structurally, and its recognition by antibodies is poorly understood. We report a comprehensive genetic and structural analysis of four independent broadly reactive antibody lineages that target a common epitope within the GP2 wing, including macaque antibodies CM10, CM11.1, and CM12.1 and murine antibody 30G4. Co-crystal structures reveal the recognition of conserved structural determinants within the wing by all four antibodies. Immunogenetic analyses uncover common antibody sequence signatures that underlie interactions with the wing, leading in some cases to nearly identical modes of antibody binding. Our study advances the structural understanding of the GP2 wing protective region and defines conserved immunogenetic and structural features for broad antibody recognition, informing the development of vaccines and antibody countermeasures.
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Niyongabo et al. (2026) studied Marburg virus disease. Antibodies targeting GP2 wing (CM10, CM11.1, CM12.1, 30G4) was evaluated on Structural and genetic basis for antibody recognition of GP2 wing. Co-crystal structures and immunogenetic analyses of four broadly reactive antibodies revealed conserved structural determinants and sequence signatures for recognition of the orthomarburgvirus GP2 wing.
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