International Session 59　　Basic (Cancer) 2

Background : Early diagnosis of laryngeal squamous cell carcinoma(LSCC)remains challenging.Circulating microR-NAs(miRNAs or miR) , particularly miR-21 and miR-223, have emerged as non-invasive biomarkers with diagnostic and prognostic potential.Methods : PubMed, Scopus, and ScienceDirect were searched for studies evaluating circulating miR-21 and/or miR-223 in serum or plasma of LSCC patients.Evidence on diagnostic accuracy, prognostic relevance, and posttreatment expression changes was qualitatively synthesized.Results : Five studies met inclusion criteria.Circulating miR-21 was consistently upregulated in LSCC and associated with advanced stage, nodal involvement, and reduced survival, with diagnostic accuracy up to AUC 0． 857.miR-223 showed dynamic expression changes, decreasing after surgery and increasing at recurrence, supporting its role in disease monitoring.Combined assessment of miR-21 and miR-223 improved diagnostic and prognostic performance, although heterogeneity precluded pooling.Conclusions : Circulating miR-21 and miR-223 represent clinically relevant, biomarker-based tools for LSCC diagnosis, prognosis, and post-treatment surveillance.