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This review seeks to evaluate natural cross-linkers and protease inhibitors that help preserve the hybrid layer in dental adhesives.

June 14, 2026Kerala Dental JournalOpen Access

Bioactive Approaches to Hybrid Layer Preservation: A Comprehensive Narrative Review of Natural Cross-linkers and Protease Inhibitors

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Narrative review explores bioactive strategies for enhancing bond durability in adhesive restorations, indicating promising new solutions.

This review seeks to evaluate natural cross-linkers and protease inhibitors that help preserve the hybrid layer in dental adhesives.
Conducted a comprehensive literature search from 2009 to 2025 to identify relevant studies.
Reviewed the efficacy of natural cross-linkers like proanthocyanidins and inhibitors such as chlorhexidine.
Outlined emerging strategies including biomimetic remineralization and ethanol-wet bonding.
Natural cross-linkers enhance collagen stability and inhibit matrix metalloproteinases.
Protease inhibitors significantly strengthen the resin-dentin interface, reducing nanoleakage.
Bioactive approaches contribute to extending the longevity of adhesive bonds in dentistry.

Haridas et al. (2026) studied this question.

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Narrative review explores bioactive strategies for enhancing bond durability in adhesive restorations, indicating promising new solutions.