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June 14, 2026Journal of Translational Internal MedicineOpen Access

Outcomes of patients with hematological malignancies complicated with autoimmune diseases after allogeneic hematopoietic stem cell transplantation: A ten-year real-world study

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Authors

QHQiusha HuangJWJianmin WuHFH X Fu

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Overview

Randomized trial compares transplant outcomes in patients with hematological malignancies and autoimmune diseases, indicating similar survival rates to controls.

Key Points

  • This study aims to understand the outcomes of allogeneic hematopoietic stem cell transplantation in patients with hematological malignancies and autoimmune diseases.
  • Compared outcomes between 41 patients with hematological malignancies and autoimmune diseases and 123 matched controls without autoimmune diseases.
  • Measured incidence of chronic graft-versus-host disease, overall survival, disease-free survival, and nonrelapse mortality.
  • Conducted multivariable analysis to assess risk factors related to survival and disease outcomes.
  • Incidence of chronic graft-versus-host disease was higher in the autoimmune disease group (70.7% vs 26.8%, P < 0.001).
  • 3-year overall survival was 73.2% for the autoimmune disease group vs 76.3% for controls (P = 0.76).
  • No significant differences in 3-year cumulative incidence of relapse (7.7% vs 9.5%, P = 0.61) or nonrelapse mortality (23.5% vs 16.7%, P = 0.40).

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4632b1cc60ccdea8af78https://doi.org/10.1515/jtim-2026-0031
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Novel insights from a large cohort: Elucidating incidence, risk factors, treatment, and prognostic predictors in autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation2026
  2. 2Factors influencing overall survival and GvHD development after allogeneic hematopoietic stem cell transplantation – single centre experience2024
  3. 3Premature cardiovascular disease after allogeneic hematopoietic stem-cell transplantation2007 · 234 citations
  4. 4Real-World Challenges of Haplo-Identical Hematopoietic Stem Cell Transplant in a Developing Country: A Single Center Experience2024 · 1 citations
  5. 5Does autoimmune disease impair the survival of hepatocellular carcinoma patients undergoing liver resection? A multi-institutional observational study2024