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June 14, 2026Current Pharmaceutical Biotechnology

Randomized Controlled Trial of a Nicotine Dependence Intervention:Evaluating the Efficacy of a Lemongrass (Cymbopogon citratus) Inhaler viaModulation of Nicotinic Acetylcholine Receptors

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Authors

KKKumboyono KumboyonoASArie SrihardyastutieYKYuliana Ratna Kumala

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Overview

Randomized trial evaluates lemongrass inhaler to reduce nicotine dependence in smokers, suggesting a novel adjunct therapy.

Key Points

  • This study aims to evaluate the effectiveness of a lemongrass inhaler in reducing nicotine dependence through its impact on nicotinic acetylcholine receptors.
  • Randomized, pretest-posttest controlled group design
  • Involves 100 adult smokers with moderate-to-high nicotine dependence
  • Participants received either a 3% lemongrass inhaler or a placebo for eight weeks, administered four times daily.
  • Lemongrass group showed a mean FTND score reduction of 2.3 (p < 0.001) compared to placebo
  • Serum nAChRs levels in the lemongrass group decreased by 0.6 ng/mL (p = 0.003) vs. placebo
  • ANCOVA indicated a large treatment effect (partial η² = 0.390) for lemongrass inhalation.

Cite This Study

Kumboyono et al. (2026) studied this question.

synapsesocial.com/papers/6a2e46dbb1cc60ccdea8b8a6https://doi.org/10.2174/0113892010455442260522064407
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy of Cymbopogon citratus Aromatherapy Inhaler on Sleep Quality Among Smokers: A Controlled Clinical Study2026
  2. 2GC-MS Profiling and Literature-Based Mechanistic Prediction of Lemon Essential Oil and Mango Leaf Extract as Potential Supportive Candidates for Nicotine Addiction Management2026
  3. 3Use of a natural compound based on essential oils as a potential complementary therapeutic approach to smoking cessation2024
  4. 4Comparative evaluation of indigenous aromatherapy and nicotine replacement therapy for nicotine dependence among transgender women in Puducherry: a randomized controlled trial2026
  5. 5The Role of Twice-Daily N-acetylcysteine (NAC) 2400 mg in Smoking Cessation: A Randomized, Placebo-Controlled Trial in Indonesia2024 · 3 citations