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June 14, 2026Current Bioactive Compounds

Determination of the Effects of Copper Coordination Compounds withThiosemicarbazones on the in vitro Formation of Advanced Glycation EndProducts of the Pentosidine-like and Vesperlysine-like Types

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Authors

VPValeriana PanteaEPEcaterina PavlovschiSSSilvia Stratulat

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Overview

Randomized trial assesses copper-thiosemicarbazone effects on AGEs in vitro, suggesting therapeutic implications.

Key Points

  • This study aims to investigate how copper-thiosemicarbazone compounds influence the formation of advanced glycation end-products (AGEs).
  • Tested various copper coordination compounds of thiosemicarbazones at concentrations of 10.0 μmol/L and 1.0 μmol/L
  • Measured levels of pentosidine-like and vesperlysine-like AGEs and compared them with controls and doxorubicin treatment.
  • Evaluated the effects of compounds on AGE levels to discern potential antiglycation properties.
  • At high concentration, doxorubicin, CMD-8, MG-22, and TIA-160 increased pentosidine-like AGE levels significantly, up to four times than control.
  • CMD-8 and MG-22 raised vesperlysine-like AGE levels, while CMC-34 decreased it.
  • Lower concentration (1.0 μmol/L) showed less pronounced modulation of AGE levels, indicating varying effects from different compounds.

Cite This Study

Pantea et al. (2026) studied this question.

synapsesocial.com/papers/6a2e472bb1cc60ccdea8bae7https://doi.org/10.2174/0115734072473961260520104546
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