What question did this study set out to answer?

To evaluate the hepatoprotective activity and molecular binding mechanisms of Elaeocarpus serratus ethanolic leaf extract against acetaminophen-induced liver damage.

August 14, 2026Current Bioactive Compounds

In vivo and In silico Hepatoprotective Activity of Elaeocarpus serratus

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Authors

VMValentina MendoncaNitte University RSRajesh Kaverikana ShankaraNitte University CSChandrashekar Kodangala SubrayaManipal Academy of Higher Education

Discussion

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Implication

Preclinical study demonstrates dose-dependent hepatoprotective effects of Elaeocarpus serratus in animal models, suggesting therapeutic utility against drug-induced liver injury.

Key Points

To evaluate the hepatoprotective activity and molecular binding mechanisms of Elaeocarpus serratus ethanolic leaf extract against acetaminophen-induced liver damage.
Assigned animals into six groups (n=6 per group): normal control, acetaminophen disease control, silymarin standard, and three plant extract doses (100, 200, and 400 mg/kg orally) administered for 7 days with acetaminophen given on day 5.
Evaluated blood serum for liver function tests and excised hepatic tissues for histopathological examination on day 7.
Conducted in silico molecular docking of 20 phytoconstituents and silymarin against six protein targets involved in hepatic toxicity pathways (PDB IDs: 3KRR, 4CIK, 5WUU, 6V7K, 6VL4, and 7XGJ).
Acetaminophen administration induced marked hepatic dysfunction as evidenced by altered liver enzyme levels and protein parameters.
Oral treatment with the leaf extract at 400 mg/kg produced significant, dose-dependent hepatoprotection and normalized biochemical indices alongside histopathological tissue recovery.
Molecular docking verified favorable binding interactions between 20 leaf phytoconstituents and the selected toxicity-mediating target proteins.

Cite This Study

Mendonca et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec764b70b84ec8b913c8d https://doi.org/10.2174/0115734072389722251028000749

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Implication

Preclinical study demonstrates dose-dependent hepatoprotective effects of Elaeocarpus serratus in animal models, suggesting therapeutic utility against drug-induced liver injury.

In vivo and In silico Hepatoprotective Activity of Elaeocarpus serratus

Discussion

Member takes

Implication

Key Points

Cite This Study

In vivo and In silico Hepatoprotective Activity of Elaeocarpus serratus

Discussion

Member takes

Implication

Key Points

Cite This Study

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