Neuroinflammatory Link between Arthritis and Central Nervous System Dysfunction, and the Therapeutic Potential of Plant-derived Bioactives: ASystematic Review
Systematic review shows plant-derived bioactives may improve neuroinflammation in arthritis, indicating a new treatment avenue.
Key Points
This review examines the connection between arthritis and central nervous system dysfunction due to neuroinflammation, focusing on plant-derived bioactives.
Literature search conducted in PubMed, Scopus, and Web of Science.
Included mechanistic research on neuroinflammation, blood-brain barrier dysfunction, and plant-derived bioactives.
Organized findings into key areas such as peripheral signaling and molecular pharmacology.
Pro-inflammatory cytokines and gut endotoxins increase microglial activation and cognitive impairment.
Plant bioactives like curcumin and quercetin show dual joint and neuroprotective effects with specific IC50 values for targeting inflammation.
Advanced delivery systems enhance plant bioactive bioavailability, yet challenges like standardization impede clinical application.