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This study aims to determine the median effective volume of 0.2% ropivacaine for axillary brachial plexus block in children aged 6–10 years.

June 14, 2026Pediatric DiscoveryOpen Access

Median Effective Volume of 0.2% Ropivacaine for Ultrasound‐Guided Axillary Brachial Plexus Block in Children Aged 6–10 Years: A Prospective Dose‐Finding Study Using Up‐and‐Down Sequential Allocation

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Prospective dose-finding trial identifies optimal volume of ropivacaine for pediatric nerve blocks, indicating precision in dosing.

This study aims to determine the median effective volume of 0.2% ropivacaine for axillary brachial plexus block in children aged 6–10 years.
Conducted a double-blind, dose-finding trial using the Dixon up-and-down method.
Enrolled pediatric patients aged 6–10 years undergoing unilateral elbow or below-elbow surgery.
Adjusted the volume of ropivacaine (0.2%) based on the previous patient's response until seven inflection points were observed.
The median effective volume (EV 50) was 0.350 mL/kg (95% CI: 0.197–0.362 mL/kg).
The 95% effective volume (EV 95) was 0.395 mL/kg (95% CI: 0.385–0.396 mL/kg).
No adverse events were reported during the perioperative period.

Ahmad et al. (2026) studied this question.

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