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June 14, 2026Current Pharmaceutical Design

Kunxian Capsule Exerts Antitumor Effects by Activating the IL-17 Signaling Pathway to Inhibit the Proliferation, Apoptosis, Cell Cycle, and Induce Reactive Oxygen Species Production in C8166 Tumor Cells

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Authors

XWXiaodan WangXMXiaona MaCFChunsheng Fang

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Overview

Randomized trial demonstrates tumor suppression in C8166 cells, suggesting KXJN's therapeutic potential.

Key Points

  • This study investigates the antitumor effects of Kunxian capsule (KXJN) on C8166 tumor cells by activating the IL-17 signaling pathway.
  • Network pharmacology identified potential targets and pathways related to KXJN and A-ATL.
  • C8166 cells were treated with KXJN to assess tumor growth, apoptosis, cell cycle dynamics, and reactive oxygen species (ROS) production using various assays.
  • Western blot and RT-qPCR analyzed protein and mRNA expression levels of key targets and cytokines.
  • KXJN inhibited C8166 proliferation dose- and time-dependently, promoting significant apoptosis.
  • IL-17 pathway activation was confirmed with upregulation of associated proteins such as ACT1, IL-17RA, and TRAF6.
  • Increased ROS production was observed alongside changes in cell cycle progression.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a2e472bb1cc60ccdea8bc9ehttps://doi.org/10.2174/0113816128447050260521075026
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