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July 28, 2022Pharmacological Research - Modern Chinese MedicineOpen Access

The combination of KuShen and XiYangShen (KX) ameliorated myocardial injury and dose-dependently inhibited the secretion of inflammatory factors in an animal model of myocarditis.

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Why the study?

The active components and mechanisms of action of KuShen and XiYangShen combination therapy for treating myocarditis remain unclear.

Does the combination of KuShen and XiYangShen (KX) improve myocardial injury and reduce inflammatory factors in an experimental autoimmune myocarditis model?

Population

Experimental autoimmune myocarditis animal model

Comparison

KX treatment vs untreated experimental autoimmune myocarditis

Design

Network pharmacology and animal experimental study

Key result

The combination of KuShen and XiYangShen (KX) ameliorated myocardial injury and dose-dependently inhibited the secretion of inflammatory factors in an animal model of myocarditis.

Authors

MLMenghui LiuYLYue LinXHXU Huibo

Discussion

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Member takes

Overview

Hypothesis-generating for KX in myocarditis models; leaves open clinical translation pending human trials.

Structured PICO

Does the combination of KuShen and XiYangShen (KX) improve myocardial injury and reduce inflammatory factors in an experimental autoimmune myocarditis model?

P
Population
Experimental autoimmune myocarditis (EAM) animal model
I
Intervention
Combination of Sophorae Flavescentis Radix (KuShen) and Panacis Quinquefolii Radix (XiYangShen) (KX)
C
Comparator
Untreated experimental autoimmune myocarditis (EAM) group
O
Outcome
Myocardial injury and levels of inflammatory factors (TNFα, IL-1β, IL-6, and IL-17)surrogate

The combination of KuShen and XiYangShen ameliorates myocardial injury in experimental autoimmune myocarditis by inhibiting inflammatory factor secretion and modulating the Th17 cell differentiation pathway.

Cite This Study

Liu et al. (2022) studied Myocarditis. Combination of KuShen and XiYangShen (KX) vs. Experimental autoimmune myocarditis (EAM) group was evaluated on Myocardial injury and inflammatory factor secretion. The combination of KuShen and XiYangShen (KX) ameliorated myocardial injury and dose-dependently inhibited the secretion of inflammatory factors in an animal model of myocarditis.

synapsesocial.com/papers/6a207b41cbc595e19031830fhttps://doi.org/10.1016/j.prmcm.2022.100141
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Combination of<i>Sophora flavescens</i>alkaloids and Panax quinquefolium saponins modulates different stages of experimental autoimmune myocarditis via the NF‑κB and TGF‑β1 pathways2022 · 7 citations
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