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June 14, 2026The American Surgeon

Different Surgical Strategies in Colorectal Cancer Patients With Synchronous Liver Metastasis: A Meta-Analysis

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Authors

HBHaitham M. Azmy BasiounyASAli A. ShafikAAA AHMED

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Overview

Meta-analysis evaluates liver-first, colon-first, and simultaneous resection strategies in colorectal cancer with liver metastasis, suggesting no survival advantage for any approach.

Key Points

  • This meta-analysis evaluates the outcomes of different surgical strategies in colorectal cancer patients with synchronous liver metastases.
  • Systematic review of literature across multiple databases including PubMed and Cochrane.
  • Data extraction and analysis performed using Review Manager software.
  • Comparison of three surgical approaches: colon-first, liver-first, and simultaneous resection.
  • Simultaneous resection showed comparable 1-year overall survival rates (90.1% vs 87.9%) to the colon-first approach.
  • No significant differences in 3-year (66.5% vs 56.2%) and 5-year survival rates (48% vs 40.7%) between techniques.
  • Overall, no single surgical strategy provided a clear survival advantage.

Cite This Study

Basiouny et al. (2026) studied this question.

synapsesocial.com/papers/6a2e482cb1cc60ccdea8c7cahttps://doi.org/10.1177/00031348261460472
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systematic Review and Meta‐Analysis of Resection Sequence in Synchronous Colorectal Liver Metastasis: Primary vs. Liver First2026
  2. 2Liver-First Resection in Patients With Synchronous Colorectal Liver Metastases Is Associated with Inferior Recurrence-Free Survival: Reconsidering the Importance of the Primary Cancer2024 · 1 citations
  3. 3Surgical Resection in Colorectal Liver Metastasis: An Umbrella Review2024 · 4 citations
  4. 4“Two-stage resection of synchronous liver metastases in colorectal cancer leads to a survival benefit: a retrospective comparative cohort study”2025 · 2 citations
  5. 5THE "LIVER-FIRST" APPROACH IN THE SURGICAL TREATMENT OF PATIENTS WITH SYNCHRONOUS METASTASES OF COLORECTAL CANCER IN THE LIVER: RESULTS OF A SINGLE-CENTER STUDY2024 · 1 citations