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June 17, 2026Journal of Surgical OncologyOpen Access

Systematic Review and Meta‐Analysis of Resection Sequence in Synchronous Colorectal Liver Metastasis: Primary vs. Liver First

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Authors

SMSofoklis MavrantonisOEOmar Abou El‐WafaSVSascha Vaghiri

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Overview

Systematic review compares outcomes of colorectal first vs. liver first resections in patients with synchronous colorectal liver metastases, suggesting notable differences in survival.

Key Points

  • The study aims to compare overall survival, disease-free survival, morbidity, and mortality between colorectal first and liver first resections in patients with synchronous colorectal liver metastases.
  • Conducted a systematic literature search in multiple databases following PRISMA guidelines.
  • Assessed heterogeneity among studies using the Cochrane Q test and inconsistency tests.
  • Synthesized data from fifteen studies, including 8611 patients published from 2010 to 2025.
  • CRf group showed statistically significant higher 1-year overall survival compared to the Lf group.
  • CRf group demonstrated significant benefits in 1-, 3-, and 5-year disease-free survival rates compared to Lf.
  • No significant differences were observed in major morbidity and 90-day mortality between the two groups.

Cite This Study

Mavrantonis et al. (2026) studied this question.

synapsesocial.com/papers/6a323cc9d50b63ecad206d52https://doi.org/10.1002/jso.70309
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Liver-First Resection in Patients With Synchronous Colorectal Liver Metastases Is Associated with Inferior Recurrence-Free Survival: Reconsidering the Importance of the Primary Cancer2024 · 1 citations
  2. 2Surgical Resection in Colorectal Liver Metastasis: An Umbrella Review2024 · 4 citations
  3. 3Different Surgical Strategies in Colorectal Cancer Patients With Synchronous Liver Metastasis: A Meta-Analysis2026
  4. 4“Two-stage resection of synchronous liver metastases in colorectal cancer leads to a survival benefit: a retrospective comparative cohort study”2025 · 2 citations
  5. 5Clinical Outcomes of the Liver-First Approach in the Management of Synchronous Colorectal Liver Metastases: A Retrospective Study2024